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Abbreviated as AMS this condition is somewhat rare and results in the dog slowly but progressively over-grooming (licking) or biting their pads and paws leading to bleeding and ulceration. This leads to bacterial and fungal infections and in many cases ulcers.

Symptoms can be managed by using 'Elizabeth' cones or anti-anxiety medication. if the disorder cannot be managed then euthanasia is common.

It is neurological seen in a mutation of the GDNF gene affecting the development of the axon in the dog's neurons, this leads to a decrease in the sensation to recognise pain and temperature sensation.

Autosomal Hereditary Recessive Nephropathy (Familial Nephropathy) is an inherited disorder of the kidneys. 

Symptoms include excessive thirst and urination, weight loss, fatigue, vomiting, and loss of appetite. Protein is generally not present in urine, however in there is a defect in affected dogs that filters protein from the blood to the kidneys and subsequently lost in the urine.

Bernard-Soulier syndrome (BSS) is an inherited autosomal recessive lethal bleeding disorder occurring in English Cocker Spaniels characterized by low platelet count, unusually large platelets compared to the standard size and substantially worse blood clotting. It is caused by lack of glycoprotein that is normally found on the surface of blood platelets and acts as a receptor of another protein found in the circulating blood called von Willebrand factor (vWF).

This is an autosomal recessive condition that affects Labradors, as well as several other related breeds. The condition is also seen in mixed breeds.

With vigorous exercise lasting 5-20 minutes, a loss of control becomes apparent in the hind limbs. Starting as a wobbly gait, the loss of control progresses to collapse, and sometimes dogs may seem confused.

Progressive retinal atrophy (PRA) encompasses inherited retinal diseases leading to blindness in dogs, with varying onset ages and inheritance patterns specific to each breed. Symptoms typically start with night blindness, progressing to complete blindness over time. While PRA itself isn't painful, complications like cataracts can cause discomfort.

PFK deficiency in dogs is a genetic disorder affecting glucose metabolism due to insufficient enzyme activity. It causes muscle weakness, fatigue, and exercise intolerance, with symptoms including brown urine and occasional severe anaemia episodes.